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And in Novo Nordisks CagriSema trial, 40% of participants did lose at least 25% of their body weight just not enough to bump the trials overall average result past that benchmark

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The 1 mg dose has direct human diabetes-trial activity. Below 1 mg is more speculative

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Clinical Update 4/04/2023 Coffees Effects on Heart Rhythm, Sleep Does drinking caffeinated coffee cause heart palpitations, or reduce sleep

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