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Over time, the brain reduces its own production of these chemicals to compensate, meaning that in the absence of alcohol, dopamine drops and anxiety rises, triggering a craving

The determination of whether a promotional communication is misleading includes, among other things, not only representations made or suggested in the promotional communication, but also the extent to which the promotional communication fails to reveal facts material in light of the representations made or with respect to consequences that may result from the use of the drug as recommended or suggested in the promotional communication

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