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Add-on Rehmannia-6-based chinese medicine in type 2 diabetes and CKD: a multicenter randomized controlled trial
But during perimenopause and menopause, several critical pathways slow down: Growth hormone (GH) production declines affecting muscle mass, fat metabolism, skin quality, and recovery Inflammatory markers increase contributing to joint pain, brain fog, and metabolic dysfunction Sleep architecture degrades less deep sleep means less cellular repair, less growth hormone release, and more fatigue Collagen synthesis drops dramatically women lose roughly 30% of their collagen in the first five years of menopause, accelerating skin aging, joint stiffness, and connective tissue weakness Gut lining integrity weakens leading to increased inflammation, food sensitivities, and nutrient malabsorption Sexual function changes declining hormones reduce libido, arousal, and tissue health Peptide therapy doesnt replace what menopause takes away it reactivates the pathways that menopause suppresses
We call this the Gray Zone
It can also have potential drug interactions, for example, berberine can inhibit the metabolism of blood thinners like Warfarin and increase risk for bleeding in patients who are taking these drugs
31-33 Because melatonin is produced from serotonin, it follows that sleep disturbances in DS are likely due to altered serotonin levels
Angebault C, Fauconnier J, Patergnani S, Rieusset J, Danese A, Affortit CA, et al
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