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demonstrated that the GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant Apoe/Irs2+/ mice by promoting macrophage polarization towards an anti-inflammatory M2 phenotype, which was associated with enhanced plaque stability (i.e., thicker fibrous caps, fewer necrotic cores, and decreased inflammatory infiltrates)

Aging, 14 (7), 3191-3202

By penetrating the blood-brain barrier, it enhances neural connections throughout the brain, potentially improving overall cognitive function and mental performance

PubMed 9.Koyuncu E et al

No interaction between the two compounds affects dosing timing

it also reduces fat-free mass, including muscle, bone, connective tissue, and fluids