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The drug is primarily absorbed in the small intestine, which remains anatomically intact following sleeve gastrectomy meaning absorption is less likely to be significantly compromised compared with procedures that alter the small bowel, such as gastric bypass

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BMC Nephrol 26 , 179 (2025)

Many patients experience reduced appetite and fluid intake when starting GLP-1 therapy, whilst the medicine's gastrointestinal effects including nausea and occasional vomiting can further affect hydration status

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This slow yet steady increase allows semaglutide to continue to work as designed while minimizing potential side effects