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When the diagnosis of gout is made, the individual must be evaluated for the complications of gout: Collections of uric acid (tophi) need to be searched for, and they can be in numerous locations (see Figures 7-10 )

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doi: 10.1080/1028415X.2017.1344371 81

To counteract these detrimental effects, cells rely on precise regulatory mechanisms to maintain balanced Ca 2 + levels, ensuring proper cellular function while minimizing the risk of toxicity (Nava et al., 2020

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