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This early worsening of DR with improved glycemic control has also been described in patients with type 2 diabetes treated with insulin or GLP-1 agonists, following bariatric surgery, in pregnant women with diabetes, and following pancreatic transplants in patients with type 1 diabetes (35)

Retatrutide has also been studied in type 2 diabetes

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If someone is sleeping better, moving more, building strength, and finding eating easier to manage, those are strong signs that metabolic health is moving in the right direction