Appetite for change: GLP-1s and society What impact will GLP-1s have
In cells with intact KEAP1-NRF2 system, transiently stabilized NRF2 induces transcriptional activation of genes encoding xCT, SLC7A11 , and two subunits of gamma-glutamylcysteine ligase (GCL), GCLC and GCLM , in response to oxidative and electrophilic stresses
Therefore, it cannot be definitively proven that the drugs themselves caused the observed advantage
We will examine the role of L-glutamine in health and propose how the extra-erythrocytic functions of L-glutamine might contribute to its beneficial effects in SCD
This activation potentially promotes the translocation of GLUT4, a major glucose transporter, to the cell surface, thus facilitating glucose entry into cells
& Woodward, E