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Excess liver cell fat promotes oxidative stress and depletes glutathione

Dosing Notes Empty stomach works best or at least 30 minutes before eating

Cells were incubated in DMEM containing 0.1% bovine serum albumin (BSA) at 37C for two days, and the medium was replaced with medium containing indicated concentrations of metformin

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Critical uncertainties persist concerning ideal candidate identification, therapeutic sequence, combination strategies with other emerging MASH therapies, long-term durability of benefits, and cost-effectiveness