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The capacity of these drugs to increase insulin secretion and suppress glucagon release leads not only to better blood sugar control but also to a better cardiovascular profile, putting them in a favorable position in the treatment of type 2 diabetes

The incretin hormone glucagon-like peptide-1 (GLP-1) exerts potent effects on glucose metabolism, prompting the development of therapeutic strategies that enhance activity of the GLP-1 receptor (GLP-1R) pathway

Pre-workout timing appears to offer more immediate performance benefits, but the overall daily dose and consistency matter more than precise timing around exercise

However, at this stage its not clear if SURMOUNT-5 is designed to detect Mounjaros superiority (rather than non-inferiority)

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Diabetes 63:31723174 Meier JJ, Nauck MA (2004) Clinical endocrinology and metabolism