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The general increase in the abundance of many small peptides in IC/BPS is consistent with prior studies showing increased protease abundance in urine/bladder cells associated with IC/BPS 23,55,56,57,58

GLP-1R are also widely expressed in brainstem and hypothalamic regions implicated in appetite control (90)

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Effects of Hardaliye, a fermented grape drink, on oxidative stress, lipid profile, and blood pressure in young soccer players: A randomized controlled trial

Each of these steps contributes to better outcomes

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