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It differs from native IGF-1 by having an arginine substitution at the third amino acid (R3) and an additional 13 amino acids at the N-terminus, making it significantly more potent in receptor activation studies

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C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

et al(2023) Antrodia cinnamomea May Interfere with the Interaction Between ACE2 and SARS-CoV-2 Spike Protein in vitro and Reduces Lung Inflammation in a Hamster Model of COVID-19

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This can lead to a reduction in MTHFR enzyme production - potentially up to 65% less than healthy levels