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[3] Kim, D., & Cohen, P

You are using a highly advanced, validated delivery system (like liposomal) and understand its inherent variability

The naphthoquinone Atovaquone demonstrated particularly high affinity and potential dual-mode binding with the enzyme active site and cavity

However, when APAP is ingested in excessive amounts, the capacity of GSH to neutralize NAPQI becomes overwhelmed, leading to depletion of hepatic GSH stores and accumulation of NAPQI, resulting in oxidative stress, mitochondrial dysfunction, and hepatocellular injury, ultimately culminating in acute liver injury and potential liver failure

Our APAP model is a whole-body model of APAP that includes transport from the gut to the liver, the liver metabolism described in the previous paragraph, transport out of the liver to the blood, and excretion in the urine