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Key Highlights 6.2.1.1

The popularity of coffee enemas declined during the 20th century and their citation as a folk medical practice was removed from the best-selling textbook Merck Manual in 1972

In mouse liver, virus strains may have different pathogenicities in the various mouse strains and in mice of different ages (Percy and Barthold 2007)

This mineral is essential for the synthesis of serotonin and the regulation of stress reactions in the body

For these experiments, the His-tag used for purification was not removed

Limitations include heterogeneity in study designs, populations, and outcome measures, which may affect generalizability and preclude definitive causal conclusions