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Moreover, some patients may interrupt their treatment once symptoms improve, not realising the long-term necessity of ongoing supplementation to prevent recurrence of deficiency symptoms

Reduced circulating IGF-1 and growth failure were also reported in T1DM patients, while IGF-1 concentrations in renal tissue were shown to be increased, suggesting increased local synthesis and/or IGF-1 sequestration from the circulation [203, 204]

doi: 10.1016/j.toxlet.2020.04.005 166 RohwerNCramerT

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