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The reproducibility of subjective appetite scores

PMCID: PMC7737050

Medical conditions that reduce response Several conditions can blunt semaglutide effectiveness regardless of whether it is compounded or brand-name: Hypothyroidism , especially untreated or undertreated, slows metabolism and counteracts weight loss Insulin resistance and type 2 diabetes can require higher doses for the same effect PCOS creates hormonal resistance to weight loss interventions Cushing syndrome and other cortisol disorders override appetite suppression mechanisms Certain medications , including some antidepressants, antipsychotics, corticosteroids, and beta-blockers, promote weight gain through independent pathways If you have any of these conditions, semaglutide may still work but could require higher doses or additional interventions

The B12 is separate

Try: Greek yogurt with cinnamon Apple slices with almond butter Protein shakes Dark chocolate squares Cottage cheese and berries These are all healthy alternatives to sugar and great for stopping sugar cravings with medication support

NHS / East Croydon Medical Centre GLP-1 Agonists and Contraception Guidance (2025) 12