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Interaction with Nitric Oxide Pathways Nitric oxide (NO) is a signaling molecule involved in vascular tone, blood flow, and cellular communication

Cartilage itself is not innervated, but nociceptors are present in surrounding tissues, such as the synovium and joint capsule, subchondral bone, periosteum, meniscus, and ligaments 39

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Tissue Inhibitor of Metalloproteinase (TIMP) Interactions The balance between MMPs and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), determines net proteolytic activity in tissues

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