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10.1016/s0006-8993(99)01880-6 Brain Res

The continuous systemic inflammation generated by this vascular damage further depletes the body's already compromised antioxidant reserves, perpetuating the cycle of chronic illness and making recovery incredibly difficult without targeted biochemical intervention

It has also been found that ADNP is involved in histone methylation [346] and acetylation [347] upon interaction with proteins, such as the histone deacetylase sirtuin 1 (SIRT1), which regulates the transcriptional activity and epigenesis [293]