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Olympus, Tokyo, Japan)

It causes a selective loss of upper motor neurons (UMN) of the motor cortex and lower motor neurons (LMN) of the brainstem and spinal cord (Brown and Al-Chalabi, 2017

Neurons constantly fire electrical signals and maintain ion gradients that require large amounts of ATP

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The nasal mucosa surface provides substantial absorption, enabling the peptide to avoid gastrointestinal enzymatic breakdown and enter the bloodstream at comparatively high speed increasing the efficacy of the peptide blend

During the oxidation phase, accumulated ROS (such as hydrogen peroxide HO and superoxide anion O) in the cell can directly react with GSH in a non-enzymatic manner, or, under the catalysis of glutathione peroxidase (GPX), promote the oxidative coupling of two GSH molecules to form one molecule of GSSG, while releasing two protons (H) and two electrons (e)