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Unlike GLP-1 agonists such as semaglutide or tirzepatide, which work primarily through appetite suppression, AOD-9604 directly enhances fat metabolism at the cellular level through beta-3 adrenergic receptor modulation

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LEfSe is known to reduce false positives and can highlight biological consistency across subclasses, while the KruskalWallis test used alone can achieve a lower false-negative rate compared to LEfSe 38