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2019;26(10):142735.e5

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Although the mechanisms by which these reagents modulate GPx1 expression are not clear, it has been shown that GPx1 can be upregulated by activation of the peroxisome proliferator-activated receptor--coactivator-1a (PGC1) pathway, possibly via the subsequent activation of Nrf2 [161]

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Antioxidant measures consist of antioxidant enzymes, vitamins and minerals that catalyze the conversion of ROS to non-toxic molecules such as water and O2