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Renal function should be monitored, as severe gastrointestinal adverse effects can lead to dehydration and acute kidney injury, particularly in patients with pre-existing renal impairment

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Contact your healthcare provider within 24 hours for: Recurrent episodes of right upper abdominal pain, even if they resolve Persistent indigestion or bloating that is new or worsening Changes in stool color (pale or clay-colored) or dark urine Unexplained nausea that differs from typical semaglutide side effects Any abdominal pain that concerns you or interferes with daily activities Your provider may order diagnostic tests including abdominal ultrasound (the first-line imaging for gallstones), liver function tests, complete blood count, and lipase levels if pancreatitis is suspected

A 2023 study in JAMA found that people using GLP-1 drugs like Ozempic were much more likely to develop gastroparesis than those not taking these medications

The appetite regulation centers in the brain need time to adjust to sustained GLP-1 receptor activation

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