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While physicians may legally prescribe approved medications for unapproved uses, this practice raises ethical concerns about resource allocation, particularly when supply shortages exist
IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040
doi: 10.1080/00365521.2016.1249403
(iii) ROS level and immunological state
When blood sugar decreases, the effect of GLP1 receptor agonists will correspondingly weaken, so the risk of hypoglycemia is lower when using GLP-1 alone
Abbreviations AE: Adverse event BMI: Body mass index BP: Blood pressure CI: Confidence interval CV: Cardiovascular CVOT: Cardiovascular outcome trial DBP: Diastolic blood pressure ETD: Estimated treatment difference GIP: Glucose-dependent insulinotropic polypeptide GLP-1 RA: Glucagon-like peptide-1 receptor agonist HbA1c: Glycated haemoglobin A1c MACE-4: Major adverse cardiovascular events proAND: Pro-atrial natriuretic peptide SBP: Systolic blood pressure T2D: Type 2 diabetes WL-D: Weight-loss dependent WL-IND: Weight-loss independent References Petrie JR, Guzik TJ, Touyz RM
