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Supplementary Information Abbreviations AMPK Adenosine monophosphateactivated protein kinase ATC Anatomical therapeutic chemical (classification system) BMI Body mass index CI Confidence interval CKD Chronic kidney disease COPD Chronic obstructive pulmonary disease cAMP Cyclic adenosine monophosphate DM Diabetes mellitus DPP-4i Dipeptidyl peptidase-4 inhibitors GLP-1 Glucagon-like peptide-1 GLP-1RA Glucagon-like peptide-1 receptor agonist HbA1c Hemoglobin A1c HR Hazard ratio HSV Herpes simplex virus ICD International Classification of Diseases IRB Institutional Review Board LZV Live-attenuated zoster vaccine RCT Randomized controlled trial RZV Recombinant zoster vaccine SD Standard deviation SGLT-2i Sodium-glucose co-transporter-2 inhibitor SLE Systemic lupus erythematosus SMD Standardized mean difference SNOMED Systematized Nomenclature of MedicineClinical Terms STROBE Strengthening the Reporting of Observational Studies in Epidemiology VZV Varicella-Zoster virus Authors contributions CHH, IHC, ICL, PHL, ITL, and JCW conceived and designed the study

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