glp-1/gip/glucagon triple agonist name Dual and Gut Peptide Agonists on the Horizon for the Treatment of Type 2 Diabetes and Obesity. An Overview of Preclinical and Clinical Data | Current Obesity Reports Dual and Triple Gut Peptide

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An excessive increase in glutamate contributes to glucose-toxicity in -cells via activation of pancreatic NMDA receptors in rodent diabetes

In addition to GABAergic signaling, astrocytes play a fundamental role in maintaining glutamate homeostasis, which is essential for modulating tonic activation of N -methyl- D -aspartate receptors (NMDARs) [284, 306], typically composed of two GluN1 subunits and either two GluN2A or two GluN2B subunits [307]

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