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Mechanisms of Hepatocyte Growth Factor Activation in Cancer Tissues

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The canonical entity remains Melanotan II

57 , 206 (2025a)

GH exerts autocrine/paracrine effects by binding to GHR in the same or a neighboring cell surface and initiating JAK2- and SRC-mediated signaling cascades, which decrease pro-apoptotic molecules (Bax and PPAR) and suppress caspase protein activation (Figure 4A)