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HR) for death

In the mid of 1980s, it was observed that insulin resistance (IR) was associated with the aging process in human tissues [167, 168]

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Furthermore, quantification of hepatocellular vacuolation (a characteristic of cellular degeneration observed through tissue pathology staining) at the 2-h time point revealed a 1.5-fold greater area of liver degeneration in hepsin / mice compared with wild-type mice, which increased to ~ 2.5-fold greater by the 6-h time point (Fig