Eligibility criteria Inclusion criteria were summarized according to the PICOS principle: (1) P (Participants): No restriction on diseases
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Incidence Data emerging from randomized clinical trials (RCTs) shows that the frequency and the incidence of irAEs usually depend on the ICI agent used, duration of exposure, dose and patients risk factors profile
Furthermore, NADPH is replenished by the isocitrate dehydrogenase (IDH1/IDH2) branch of the citric acid cycle (TCA cycle), malic enzyme (ME1), and one-carbon metabolism (such as the folate cycle) depending on cell type or nutritional status
Bibliografia Khavinson VK, Bondarev IE, Butyugov AA (2003)