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Research in animal models, particularly rodents, has shown that prebiotic and probiotic interventions can reshape the composition and functional activity of the gut microbiota, thereby modulating neurochemical signaling and attenuating neuroinflammatory processes within the brain (451)

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doi: 10.3389/fimmu.2025.1604652 Received 02 April 2025 Accepted 23 May 2025 Published 06 June 2025 Volume 16 - 2025 Edited by Zhengyu Jiang, Second Military Medical University, China Reviewed by Feng Zhang, Nanjing University of Chinese Medicine, China Fangyang Fan, Beijing University of Chinese Medicine, China Updates Copyright 2025 Xia, Li, Shi, Sun and He

The side-effect profiles look broadly similar because both drugs share GLP-1 and GIP activity