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Acknowledgements The authors wish to thank the Department of Biology and the Research Council of Islamic Azad University, Rasht Branch, for providing laboratory support and scientific guidance throughout the study

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Indeed, pioglitazone-induced heart failure (HF) and the withdrawal of rosiglitazone because of cardiovascular concerns eventually led to a change in the policy of regulatory authorities.9,10 The US Food and Drug Administration and the European Medicines Agency now require all new antidiabetic drugs to undergo large cardiovascular outcome trials (CVOTs) to confirm cardiovascular safety and benefits

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