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17 The retrospective study found that subcutaneous semaglutide use was statistically significantly associated with the risk of developing NAION, no matter what the medications reason for use: patients with type 2 diabetes had a 4.28 HR compared to control (n=17 vs 6), while patients who used the medications for weight loss had a 7.64 HR compared to control (n=20 vs 3)

The paper notes that AUD often worsens mood symptoms and increases suicide risk in bipolar disorder, but it did not directly measure blood ethanol concentrations or suicide risk reduction in this patient

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However, the question remained on whether the possible beneficial therapeutic actions of GLP-1 RA in PCOS might depend exclusively on the improvement in body weight and metabolic profile or on direct effects on HPG axis in PCOS