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Anti-Inflammatory Activity: Reduces TNF-alpha-induced IL-6 secretion in human dermal fibroblasts, with proposed anti-inflammatory benefits

An abundance of the microbial metabolite tryptophan has been observed in the gut of SLE patients and lupus-prone mice and is considered to shift the composition of the gut microbiome (123, 127, 128)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Karagiannis ED, Popel AS

This was reported more frequently at the 9 mg and 12 mg doses in TRIUMPH-4 than with placebo