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G15, a widely used selective GPER antagonist, has been shown to effectively inhibit GPER-mediated biological responses in various cellular models [227]

Nonetheless, our study demonstrates that a persistent imbalance between oxidative stress toxicity and reduced ANTIOX is a key component of Long COVID and that increased aldehyde, neutrophil-associated MPO, protein carbonyl, and NO production are the major neurotoxic pathways, which, when combined with decreased ANTIOX, may have a variety of detrimental effects as reviewed before [81]

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Clin Biochem Rev