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2024 Mar 14 doi: 10.1038/s41380-024-02498-5

In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [2-, 11-, and 30-fold the maximum recommended human dose (MRHD) of 2 mg/week, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (1-, 2-, and 7-fold MRHD) were administered to the females

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Eating too little may lead to fatigue, dizziness, constipation, headaches, poor workouts, hair shedding, or trouble meeting protein and micronutrient needs

Though both the exposure and comparison cohorts were drawn from the same platform, which should not significantly impact the relative hazard rate ratios, results from the TriNetX platform need to be validated in other populations and platforms of EHRs

But I was surprised to see dysaesthesiawhich manifests as skin sensitivity/tingling/burning/neuropathic painreported in 22.9% at 7.2 mg vs 6.0% at 2.4 mg and 0.5% with placebo