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2018) and grown in Leibowitzs L-15 Glutamax medium supplemented with 10% FBS, 1% penicillin/streptomycin and 30 M -merceptaethanol (Sigma-Aldrich, St-Louis, MO, USA)

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Remarkably, ER-, but not ER-specific ligands, lead to increased phosphorylation of ERK 1/2, which initiates cell cycle entry (demonstrated by the up-regulation of mitotic markers such as CDK1/cdc2 and PCNA), DNA replication, and duplication of the centrosome -the major microtubule-organizing center in the cell- in dividing cells (Wang et al., 2008)

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