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Persistent or repeated exposure to non-biodegradable or slowly cleared nanomaterials may therefore shift an initially adaptive microglial response toward chronic neuroinflammation, synaptic dysfunction, and neurodegeneration, particularly in aged or disease-susceptible brains (169)

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These results are consistent with prior studies showing that antioxidants such as NAC can lower heavy metal concentrations by promoting their excretion and reducing oxidative stress in tissues

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