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Blood tests to assess liver function, kidney function, and markers of inflammation may be appropriate

Semaglutide is not recommended for patients with personal or family history of medullary thyroid carcinoma or MEN 2 syndrome

3 Surgical interventions are often used for advanced-stage IDD 4 to address severe neurological symptoms in an effort to restore the height and maintain stability of the intervertebral space

When assessing baseline characteristics by comparator (Additional file 4: Appendix Table S4C), the proportion of subjects with heart failure, other prior CV events and prior insulin use was higher, and mean eGFR was lower, in the placebo and semaglutide groups than in the other comparator groups, driven by the large patient numbers and high baseline CV risk in the CVOTs

Journal of Hepatology 80(2): e54e56

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