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The 49 known ABC transporters are typically comprised of two domains, a highly conserved nucleotide-binding domain and a largely variable transmembrane protein domain (254)

ACS Med Chem Lett 8:560565

The interaction with tirzepatide is theoretical but worth noting: both medications can potentially affect cardiac rhythm

19 We speculate that patients with clEDS may be more prone to have structural defects along the walls of the gastrointestinal tract, which can predispose to diffuse diverticulosis, diverticulitis, and resulting bowel perforation as well as to perforation during invasive procedures and spontaneous perforation

Separating the effects of the medication from the effects of the underlying disease is something researchers are still actively working through

Volumes more than 10 ml should be split and given at separate intramuscular or subcutaneous sites