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Lee DH, Steffes MW, Sjdin A, Jones RS, Needham LL, Jacobs DR Jr

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According to Lee et al., Chrysin and 5-Fu worked together to enhance the anticancer effects of 5-Fu and overcame 5-Fu resistance in vitro by further upregulating p53 and subsequently stimulating p21 activity to block arrest in AGS/5-Fu cells (170)

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Usage tips : After cleansing your skin, apply the cream on your body morning and evening using circular massage