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Always check which estimand a headline number is using before comparing across trials

The phase 3 TRIUMPH-4 trial confirmed these findings

This enhances GABAs ability to inhibit excitability in the CNS similar to the administration of benzodiazepinesalthough, crucially, without their associated side effects and addictive potential [1]

All safety data comes from animal models (primarily rats and mice)

Autoimmune and neurologic conditions Conditions like multiple sclerosis (MS) can cause episodic numbness

Across most animal and human studies, two primary routes dominate [1]: Subcutaneous injection : Used in numerous rodent studies (typically 0.110 g/mouse/day) and in human trials (commonly 0.51 mg/day), especially in circadian and immune studies