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The SUSTAIN-6 trial showed a significant reduction in major adverse cardiovascular events (MACE), including non-fatal myocardial infarction and non-fatal stroke, specifically in patients with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors

Thursdays vote tally reflected the unusual makeup of the panel

What they found was cost dominates treatment decisions: 68% said cost influenced their decision to start or continue treatment 44% said the medication cost more than they expected Cost surpassed side effects as the #1 reason people stopped taking GLP-1s A breakdown of the financial burden: 24% pay more than $250 per prescription fill Nearly 8% pay $500 or more per fill 24% said insurance didn't cover any cost Weight management patients were nearly twice as likely to pay $250+ vs diabetes patients --- Here's what patients are thinking: Nearly 40% ended up using discount programs or manufacturer coupons 60% know someone who wants GLP-1s but can't afford them 83% believe Americans turn to DTC programs because traditional healthcare is too expensive Patients still prioritize safety: 60% are aware of safety risks with non-FDA-approved GLP-1s--this one surprised me

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The Treasury Judgment Fund, which processes payments, was also suspended, leaving thousands of claimants in limbo

They are also combining GLP-1s for fat loss with muscle-preserving medications, so for a different mechanism of action in obesity and type 2 diabetes