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They concluded that while GHK-Cu does demonstrate anti-wrinkle effects in cellular studies, "there is a surprising absence of clinical studies using them." The review identified skin permeation as the central challenge: GHK's high aqueous solubility and low partition coefficient work against transdermal absorption

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But studies have shown that GLP-1s can help you lose weight and improve blood sugar

This is a high-risk population, and historically weve had limited data to guide treatment decisions, said Amy Sheer, MD, associate professor of medicine and director of the Obesity Medicine Fellowship program at the University of Florida