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[2] However, monodehydroascorbate is a radical and if not rapidly reduced it disproportionates into ascorbate and dehydroascorbate (DHA)

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The mechanisms by which bilirubin reacts with oxygen radicals are not completely understood, however its hydrophobic tetrapyrrole structure has been reported to be an inhibitor of NADPH oxidase and protein kinase C (PKC) among other mediators of pro-arteriogenic factors (58-60)

PMCID: PMC5798128.10.1093/ckj/sfx101 [PMC free article: PMC5798128] [PubMed: 29423206] [CrossRef] 369