The overall discontinuation rate was 4.3% to 7.1% (Jastreboff et al., NEJM 2022)
This introduces contaminants and oxidises the peptide over repeated draws
Feb 2019;4(1):102-108
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[DOI] [PubMed] [Google Scholar] Navrot N, Gelhaye E, Jacquot JP, Rouhier N
Their main disadvantages, however, are their high cost, long lifespan, and the need for specialized large-animal facilities