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When neurological symptoms are present, more intensive treatment is required: 1 mg hydroxocobalamin on alternate days until no further improvement occurs, followed by maintenance therapy every two months

In the research framing, judging the protocol by the fast signal is a mistake the endpoint that carries the human data is the slow one

PST (2 p.m

For neurological involvement, hydroxocobalamin 1mg should be given on alternate days until no further improvement, before moving to maintenance

It is commonly used to address vitamin deficiencies due to poor diet, malabsorption, or certain medical conditions like anemia or chronic illnesses

Additionally, there is a potential synergistic role for vitamin B12 with copper, manganese, selenium and zinc in oxidative metabolism