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instead, they provide drug unpredictably, in a way that regulatorscorrectlycannot accept for dose-critical indications ( 5 Dose escalation, gastrointestinal class effects, and economic constraints When the elimination half-life is short and steady-state accumulation is negligible, the most intuitive response in oral peptide and protein development has been dose escalation

Some patients, however, may benefit from an increased dose to 1 mg once a week