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The phase 2 Exenatide PD2 trial reported a 3.5-point improvement on the Movement Disorder Society Unified Parkinsons Disease Rating Scale part III (MDS UPDRS Part III), and the benefit lasted through a 12-week washout, which suggested possible disease modification

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Mounjaro and Zepbound (tirzepatide) work slightly differently, targeting both GLP-1 and GIP receptors for potentially enhanced effects

Consistency matters: For steady benefits in sleep quality and regulation of sleep-wake cycles or circadian rhythm, youll typically need to commit to a regular nightly routine rather than expecting dramatic immediate results

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And so anything thats affecting energy homeostasis in the brain and body has implications for that organ called the brain