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Resulting peptide solutions were analyzed by liquid chromatographytandem mass spectrometry (LCMS/MS) performed using UltiMate 3000 RSLCnano system (Thermo Fisher Scientific) on-line coupled with Orbitrap Fusion Lumos Tribrid mass spectrometer (Thermo Fisher Scientific)

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Fumarate and aKG are key intermediate metabolites of the TCA cycle and are supported by anaplerotic pathways

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Therefore, Ipamorelin may not only serve as a growth hormone secretagogue in acute assays, but also as a tool for conditioning somatotroph populations

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