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10.3389/fendo.2021.645617 22 Merck (2017)

At the party, they discussed the therapeutic potential of GLP-1

Overall, adverse events were predominantly mild to moderate and did not lead to treatment discontinuation in most cases

mTOR contributes to more than 700 different phosphorylation reactions including the tuberous sclerosis/TSC1 (hamartin)-TSC2 (tuberin) complex, which itself dampens the mTOR/S6K/4E-BP pathway (i.e., ribosomal protein S6 kinase 1/S6K and eukaryotic translation initiation factor 4E-binding protein/4E-BP) [18]

These may be prioritised before or alongside GLP-1 receptor agonists in appropriate patients

Both are safe when prescribed by licensed providers