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The STEP-1 trial demonstrated mean weight loss of 14.9% with weekly semaglutide.[1] The SURMOUNT-1 trial showed 20.9% with tirzepatide.[2] The SELECT cardiovascular outcomes trial revealed a 20% reduction in major adverse cardiovascular events among non-diabetic patients with obesity.[3] These are not supplements
Later that same year the orforglipron structure (Kawai et al) showed the now-recognised Trp33 ECL1 anchor that underlies the human-receptor selectivity of the modern small-molecule series
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